Applied Engineering & Physics
Conrad James is a Principal Member of Technical Staff at Sandia National Laboratories. He graduated with a B.S. in electrical engineering from the University of Notre Dame and received his master’s and doctoral degrees in applied and engineering physics from Cornell University. Currently, Conrad is in the Bio/Chem/Physical Microsensors department where he serves as the Principal Investigator for the Hardware Acceleration of Adaptive Neural Algorithms (HAANA) Grand Challenge Laboratory Directed Research and Development project. This project is a major investment from the laboratory that is focused on developing disruptive technologies for data-driven computing using neural-inspired algorithms and hardware architectures.
Conrad’s experience in microsystems design and fabrication has had impact in a diverse array of fields from neural engineering to microfluidics and microelectronics. He has published over 30 research articles in peer-reviewed scientific journals and has been awarded six patents. He is a member of the Institute of Electrical and Electronics Engineers.
Neural Engineering and Neuroscience
- Chemical and topographical substrate design for living cell interfacing
- Electrophysiology of in vitro dissociated neuron and tissue-slice preparations
- Microelectrode array sensor development
- Neural-inspired algorithm development
- In vitro platforms for living cell interrogation (impedance spectroscopy, fluorescence microscopy)
- Gas phase microvalve design and simulation
- Electrokinetic phenomena in liquid-phase systems
- Resistive memory and multiferroic device technologies
- Agarwal, S., Quach, T., Parekh, O., Hsia, A.H., DeBenedictis E.P., James, C.D., Marinella, M.J., Aimone, J.B. “Energy scaling advantages of memristor crossbar based computation and its application to sparse coding,” Front Neuro 2016, 9, 484.
- Vineyard, C.M., Verzi, S.J., James, C.D., Aimone, J.B., Heileman, G.L. “Repeated play of the SVM game as a means of adaptive classification,” International Joint Conference on Neural Networks 2015, 1-8.
- Vineyard, C.M., Verzi, S.J., James, C.D., Aimone, J.B., Heileman, G.L. “MapReduce SVM game” International Neural Network Society meeting on Big Data 2015, Procedia Comp Sci, 53, 298.
- Cox, J.A., James, C.D., Aimone, J.B. “A signal processing approach for cyber data classification with deep neural networks,” Complex Adaptive Systems 2015, Procedia Comp Sci, 61, 349.
- Baca, M., Schiess, A.R.B, Jelenik, D., James, C.D., and L.D. Partridge, “Induction frequency affects cortico-striatal synaptic plasticity with implications on frequency filtering,” Brain Research 2015, 1615, 80.
- Lohn, A.J., Mickel, P.R., James, C. D. and Marinella, M.J., “Degenerative resistive switching and ultrahigh density storage in resistive memory,” Appl Phys Lett 2014, 105, 103501.
- Mickel, P. R., Lohn, A. J., James, C. D. and Marinella, M. J., “Isothermal switching and detailed filament evolution in memristive systems,” Adv. Mater. 2014, doi: 10.1002/adma.201306182. (Inside back cover article)
- Mickel, P.R., Buvaev, S., Jeen, H., Finnegan, P., Biswas, A., Hebard, A.F., James, C.D., “Resolving remanent ferroelectric polarization vector components in thin film multiferroic BiMnO3 via surface and embedded interdigital microelectrodes,” Journal of Applied Physics, 2013, 114,094104.
- Mickel, P.R., Lohn, A., Choi, B.J., Yang, J.J., Zhang, M., Marinella, M., James, C.D., Williams, R.S., “A physical model of switching dynamics in tantalum oxide memristive devices,” Appl Phys Lett, 2013; 102, 223502.
- Mickel, P.R. and James, C.D., “Multilayer memristive/memcapacitive devices with engineered conduction fronts,” Eur Phys J Appl Phys 2013, 62, 30102.
- Greene, A.C., Washburn, C.M., Bachand, G.D., James, C.D., “Combined chemical and topographical guidance cues for directing cytoarchitectural polarization in dissociated primary neurons,” Biomaterials 2011; 32, 8860.
- James, C.D., McClain, J., Pohl, K.R., Reuel, N., Achyuthan, K.E., Bourdon, C.J., Rahimian, K., Galambos, P.C., Ludwig, G., Derzon, M.S., “High-efficiency magnetic particle focusing using dielectrophoresis and magnetophoresis in a microfluidic device,” J Micromech Microeng 2010; 20, 045015.
- James, C.D., Moorman, M., Carson, B.D., Branda, C.S., Lantz, J.W., Manginell, R.P., Martino, A., Singh, A.K., “Nuclear translocation kinetics of NF-B in macrophages challenged with pathogens in a microfluidic platform,” Biomed Microdevices 2009; 11, 693.
- Galambos, P.C., James, C.D., Lantz, J., Givler, R., McClain, J., Simonson, R.J., “Passive MEMS valve with pre-set operating pressures for micro-gas analyzer,” J Microelectromech S 2009; 18, 14.
- Song, H., Mulukutla, V., James, C.D., Bennett, D.J., “Dielectrophoretic gating for highly efficient separation of analytes in surface micromachined microfluidic devices,” J Micromech Microeng 2008; 18, 125013.
- Derzon, M.S., Hopkins, M.M., Galambos, P.C., Achyuthan, K.E., Bourdon, C.J., Brener, I., James, C.D. et al., “Timely multi-threat biological, chemical, and nuclide detection: a platform, a metric, key results,” Int J Tech Transfer Commercialisation 2008; 7, 413.
- Ravula, S.K., Branch, D.W., James, C.D., Townsend, R.J., Hill, M., Kaduchak, G., Ward, M., Brener, I., “A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing,” Sensor Actuat B-Chemical 2008; 130, 645.
- James, C.D., Reuel, N., Lee, E.S., Davalos, R.V., Mani, S.S., Carroll-Portillo, A., Rebeil, R., Martino, A., Apblet, C., “Impedimetric and optical interrogation of single cells in a microfluidic device for real-time viability and chemical response assessment,” Biosens Bioelectron 2008; 23, 845.
- Kumar, A, Acrivos, A., Khusid, B., James, C.D., Jacqmin, D., "Conveyor-belt method for assembling microparticles into large-scale structures using electric fields," Appl Phys Lett 2007; 90, 154104.
- Withers, G.S., James, C.D., Kingman, C.E., Craighead, H.G. Banker, G.A., "Effects of substrate geometry on growth cone behavior and axon branching," J Neurobiol 2006; 66, 1183.
- James, C.D., Okandan, M., Mani, S.S., Galambos, P.C., Shul, R., "Monolithic surface micromachined fluidic devices for dielectrophoretic preconcentration and routing of particles," J Micromech Microeng 2006; 16, 1909.
- James, C.D., Okandan, M., Galambos, P.C., Mani, S.S., Bennett, D., Khusid, B., Acrivos, A., "Surface micromachined dielectrophoretic gates for the front-end device of a biodetection system," J Fluid Eng – T ASME 2006; 128, 14.
- James, C.D, Spence, A.J., Dowell, N., Hussein, R. Smith, K., Craighead, H.G., Isaacson, M.S., Shain, W., Turner, J. “Extracellular recordings from patterned neuronal networks using planar microelectrode arrays,” IEEE Trans Biomed Eng 2004; 51, 1640.
- Bennett, D.J., Khusid, B., James, C.D., Galambos, P.C., Okandan, M., Jacqmin, D., Acrivos, A., “Combined field-induced dielectrophoresis and phase separation for manipulating particles in microfluidics,” Appl Phys Lett 2003; 83, 4866.
- Oliva Jr., A.A, James, C.D., Kingman, C.E., Craighead, H.G., Banker, G.A., “Patterning axonal guidance molecules using a novel strategy for microcontact printing,” Neurochem Res 2003; 28, 1639.
- Craighead, H.G., James, C.D., and Turner, A.M.P. “Current issues and advances in dissociated cell culturing on nano- and microfabricated substrates,” in Recent and Evolving Advanced Semiconductor and Organic Nano-techniques, Volume 3: Physics and Technology of Molecular and Biotech Systems, Hadis Morkoc, Editor; Academic Press, San Diego, CA; 251- 318, 2003.
- Dias, A.F., Dernick, G., Valero, V., Yong, M.G., James, C.D., Craighead, H.G., Lindau, M., “An electrochemical detector array to study cell biology on the nanoscale,” Nanotechnology 2002; 13, 285.
- Craighead, H.G., James, C.D., and Turner, A.M.P. “Chemical and topographical patterning for directed cell attachment,” Curr Opin Solid St M 2001; 5, 177.
- James, C.D., Davis, R., Meyer, M., Turner, A., Turner, S., Withers, G., Kam, L., Banker, G., Craighead, H., Isaacson, M., Turner, J., and Shain, W. “Aligned microcontact printing of micrometer-scale poly-L-lysine structures for controlled growth of cultured neurons on planar microelectrode arrays,” IEEE Trans Biomed Eng 2000; 47, 17.
- James, C.D., Davis, R.C., Kam, L., Craighead, H.G., Isaacson, M.S, Shain, W., and Turner, J.N. “Patterned protein layers on solid substrates by thin stamp microcontact printing,” Langmuir 1998; 14, 741.
- Craighead, H.G., Turner, S.W., Davis, R.C., James, C.D., Perez, A.M., St. John, P.M., Isaacson, M.S., Kam, L., Shain, W., Turner, J.N., Banker, G. “Chemical and topographical surface modification for control of central nervous system cell adhesion,” Biomed Microdevices 1998; 1, 49.
- Dietrich, A.M., James, C.D., King, D.R., Ginn-Pease, M.E., Cecalupo, A.J., “Head trauma in children with congenital coagulation disorders,” J Pediatr Surg 1994; 29, 28.
• Microfluidic device for acoustic cell lysis, US Patent #9,096,823; 8/4/2015.
• Passive electrically switchable circuit element having improved tunability and method for its manufacture, US Patent #8,835,272; 9/16/2014.
• Microfabricated particle focusing device, US Patent #8,425,749 4/23/2013.
• A portable dual field gradient force multichannel flow cytometer, US Patent #8,293,089; 10/23/2012.
• Microfluidic device for the assembly and transport of microparticles, US Patent #7,744,737; 6/29/2010.
• Dielectrophoretic columnar focusing device, US Patent #7,713,395; 5/11/2010.